Irradiated Donor Lymphocyte Infusion, A Novel Approach To Prevent Graft Failure During Allogeneic Bone Marrow Transplant • 797
نویسندگان
چکیده
منابع مشابه
Immunotherapy for malignant tumors using combination of allogeneic intra-bone marrow-bone marrow transplantation, donor lymphocyte infusion and dendritic cells.
We have previously shown that the combination of allogeneic intra-bone marrow-bone marrow transplantation (IBM-BMT) and donor lymphocyte infusion (DLI) using CD4+ cell-depleted spleen cells is effective in suppressing tumor growth, but that this does not induce graft-versus-host disease (GVHD) in mice. In this report, we show that formalin-fixed tumor cell-pulsed dendritic cells (FFTCP DCs) hav...
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Stem cell transplantation has allowed escalation of chemo-radiotherapy towards the limits imposed by organ toxicities other than the bone marrow, resulting in significant associated morbidity. Enhancing malignant cell kill by further manipulation of the conditioning regimen is therefore difficult and focus has shifted towards attempts to exploit graft-versus-tumor responses, including both the ...
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Delayed administration of donor lymphocyte infusion (DLI) to established mixed chimeras has been shown to achieve anti-tumor responses without graft-vs.-host disease (GVHD). Herein we show that de novo donor BM-derived T cells that are tolerant of the recipients are important in preventing GVHD in mixed chimeras receiving delayed DLI. Mixed chimeras lacking donor BM-derived T cells developed si...
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A recent study published by Bianco et all has suggested that pentoxyifylline [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine] reduces morbidity and mortality in patients undergoing bone marrow transplantation (BMT). When compared with a “good risk” control group, pentoxifylline recipients experienced less mucositis (3.7 v 18.7 days,P = .004), less hepaticvenocclusive disease (10% v 65%,P = .001), a lowe...
متن کاملCD8-depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation.
Donor lymphocyte infusions can reinduce complete remission in the majority of patients with chronic myelogenous leukemia (CML) who relapse into chronic phase after allogeneic bone marrow transplantation (BMT). Such infusions are associated with a high incidence of graft-versus-host disease (GVHD) and marrow aplasia. BMT using selective depletion of CD8+ lymphocytes from donor cells reduces the ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1998
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199804001-00818